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La perdita di oltre il 60% del peptide circolante tra la seconda e la sesta decade di vita coincide con l'insorgenza dei segni clinici dell' invecchiamento cutaneo , della ridotta guarigione delle ferite e della degenerazione dei tessuti connettivi

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When individuals ascended to similar altitudes, gradual climbing allowed for partial acclimatization, resulting in a lower incidence (50% versus 84%) and less severity

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